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cd4 depletion antibody  (Bio X Cell)


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    Bio X Cell cd4 depletion antibody
    Cd4 Depletion Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 97/100, based on 773 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti-cd4+depletion+antibody/InVivoMAb+anti-mouse+CD4/us12514919-390-14-27
    Average 97 stars, based on 773 article reviews
    cd4 depletion antibody - by Bioz Stars, 2026-10
    97/100 stars

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    other:

    Article Title: Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunity.
    Article Snippet: For in vivo depletion T cells, anti-CD4 and anti-CD8 depletion antibodies or their corresponding isotype (BioXCell) were given at 200 μg per mouse at 3 days before tumor implant.

    Article Title: EGR1 Mediated Reduction of Fibroblast Secreted-TGF-β1 Exacerbated CD8 + T Cell Inflammation and Migration in Vitiligo.
    Article Snippet: Vitiligo is a T cell-mediated depigment skin disease caused by the complex interplay between melanocyte dysfunction, environmental stimulation, and dysregulated immune signals.. Transforming growth factor-β1 (TGF-β1), which typically derives from regulatory T cells, has long been identified at low levels in the peripheral system of vitiligo patients.. Here, through RNA-sequencing and transcription factor enrichment, we revealed that in response to CD8+ T cell-secreted interferon-gamma (IFN-γ), stromal fibroblast downregulates early growth response 1 (EGR1) activity, leading to TGF-β1 deficiency.



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    A) Daily mice bodyweights measured from 0DPI to 5DPI. B) Lung viral titers expressed as plaque forming units per mL (PFU/mL) measured in lung homogenates at 5DPI. Limit of detection = 40 PFU/mL. C) Trivalent Influenza Vaccine (containing NC99 HA)-binding total IgG measured at 5DPI represented as Area under the curve (AUC) of the optical density at 450 nm (OD450) minus the background noise (OD650). Lung cell subpopulations at 5DPI are presented in panels D to H. D) Percentage of lung total T-cells (CD3+, gating: Live> CD45 + > CD3 + ). E) Percentage of T-cell subpopulations represented as the mean % of CD3% cells per group: <t>CD4</t> + cells (Gating: Live> CD45 + > CD3 + >CD4 + CD8 - ), CD8 + cells (Gating: Live> CD45 + > CD3 + >CD4 - CD8 + ), T regs (Gating: Live> CD45 + > CD3 + >CD4 + CD8 - >FoxP3 + ). CD3 + cells not included in any of the three subpopulations are categorized as “unassigned”. Statistical analysis: for comparisons among groups at several time points: Two-way ANOVA with Tukey’s multiple comparisons test using the OVA-Alum (IP) group as control for multiple comparisons. Color of the significance markers indicates the comparison they represent; for comparisons among groups at a specific time point: Kruskal-Wallis one-way ANOVA with Dunn’s multiple comparisons test using the OVA-Alum (IP) group as control for multiple comparisons. Significance is represented as:*p = 0.05 to 0.01, **p = 0.01 to 0.001, ***p = 0.001 to 0.0001, ***p < 0.0001.
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    A) Daily mice bodyweights measured from 0DPI to 5DPI. B) Lung viral titers expressed as plaque forming units per mL (PFU/mL) measured in lung homogenates at 5DPI. Limit of detection = 40 PFU/mL. C) Trivalent Influenza Vaccine (containing NC99 HA)-binding total IgG measured at 5DPI represented as Area under the curve (AUC) of the optical density at 450 nm (OD450) minus the background noise (OD650). Lung cell subpopulations at 5DPI are presented in panels D to H. D) Percentage of lung total T-cells (CD3+, gating: Live> CD45 + > CD3 + ). E) Percentage of T-cell subpopulations represented as the mean % of CD3% cells per group: CD4 + cells (Gating: Live> CD45 + > CD3 + >CD4 + CD8 - ), CD8 + cells (Gating: Live> CD45 + > CD3 + >CD4 - CD8 + ), T regs (Gating: Live> CD45 + > CD3 + >CD4 + CD8 - >FoxP3 + ). CD3 + cells not included in any of the three subpopulations are categorized as “unassigned”. Statistical analysis: for comparisons among groups at several time points: Two-way ANOVA with Tukey’s multiple comparisons test using the OVA-Alum (IP) group as control for multiple comparisons. Color of the significance markers indicates the comparison they represent; for comparisons among groups at a specific time point: Kruskal-Wallis one-way ANOVA with Dunn’s multiple comparisons test using the OVA-Alum (IP) group as control for multiple comparisons. Significance is represented as:*p = 0.05 to 0.01, **p = 0.01 to 0.001, ***p = 0.001 to 0.0001, ***p < 0.0001.

    Journal: bioRxiv

    Article Title: A combination TLR7/8 and RIG-I agonist adjuvant reverts asthmatic allergic sensitization and prevents aggravated influenza infection in OVA-sensitized mice

    doi: 10.1101/2025.06.23.659362

    Figure Lengend Snippet: A) Daily mice bodyweights measured from 0DPI to 5DPI. B) Lung viral titers expressed as plaque forming units per mL (PFU/mL) measured in lung homogenates at 5DPI. Limit of detection = 40 PFU/mL. C) Trivalent Influenza Vaccine (containing NC99 HA)-binding total IgG measured at 5DPI represented as Area under the curve (AUC) of the optical density at 450 nm (OD450) minus the background noise (OD650). Lung cell subpopulations at 5DPI are presented in panels D to H. D) Percentage of lung total T-cells (CD3+, gating: Live> CD45 + > CD3 + ). E) Percentage of T-cell subpopulations represented as the mean % of CD3% cells per group: CD4 + cells (Gating: Live> CD45 + > CD3 + >CD4 + CD8 - ), CD8 + cells (Gating: Live> CD45 + > CD3 + >CD4 - CD8 + ), T regs (Gating: Live> CD45 + > CD3 + >CD4 + CD8 - >FoxP3 + ). CD3 + cells not included in any of the three subpopulations are categorized as “unassigned”. Statistical analysis: for comparisons among groups at several time points: Two-way ANOVA with Tukey’s multiple comparisons test using the OVA-Alum (IP) group as control for multiple comparisons. Color of the significance markers indicates the comparison they represent; for comparisons among groups at a specific time point: Kruskal-Wallis one-way ANOVA with Dunn’s multiple comparisons test using the OVA-Alum (IP) group as control for multiple comparisons. Significance is represented as:*p = 0.05 to 0.01, **p = 0.01 to 0.001, ***p = 0.001 to 0.0001, ***p < 0.0001.

    Article Snippet: For the depletion of the different T-cell subpopulations, mice were injected intraperitoneally with either CD4 depleting antibody BioXCell #BP0003-1 (clone YTS 177) with a dosing of 500 μg in 100 μL PBS, CD8 depleting antibody BioXCell #BE0223 (clone 53-5.8) with a dosing 250 μg in 100μL PBS or a combination of both, 72 and 24 hr prior to the first OVA challenge.

    Techniques: Binding Assay, Control, Comparison